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The stories of three lesbian couples -- who live in the same house at different periods of time -- who are at a crossroads in their lives. In 1961, Edith loses her lover, Abby, to a stroke. Linda and Amy struggle with feminist issues in 1972. And, in 2000, Kal and Fran try to have a baby with the help of sperm donor.
The story has many twists and turns among its four main characters. Karen wants to leave her husband for "another woman". The other woman, Monica, is a former drug addict rescued from an almost certain death on the streets of Los Angeles. However, their plan to be together becomes complicated when Karen learns that her husband is terminally ill with cancer.

During her wedding ceremony, Rachel notices Luce in the audience and feels instantly drawn to her. The two women become close friends, and when Rachel learns that Luce is a lesbian, she realizes that despite her happy marriage to Heck, she is falling for Luce. As she questions her sexual orientation, Rachel must decide between her stable relationship with Heck and her exhilarating new romance with Luce.