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On New Year's night, Sandro suffers a heart attack and needs to have an emergency transplant. He ends up receiving the heart of Isadora, a transvestite owner of a beauty salon who had died a few moments before, victim of a runover. After the transplant, Isadora, in spirit, starts to follow the publicist's steps. Meanwhile, Sandro begins to notice changes in his behavior and begins to see the world in a different way.

The Alchemist assembles together a group of people from all walks of life to represent the planets in the solar system. The occult adept's intention is to put his recruits through strange mystical rites and divest them of their worldly baggage before embarking on a trip to Lotus Island. There they ascend the Holy Mountain to displace the immortal gods who secretly rule the universe.

Charlie Kaufman is a confused L.A. screenwriter overwhelmed by feelings of inadequacy, sexual frustration, self-loathing, and by the screenwriting ambitions of his freeloading twin brother Donald. While struggling to adapt "The Orchid Thief," by Susan Orlean, Kaufman's life spins from pathetic to bizarre. The lives of Kaufman and Orlean's book become strangely intertwined as each one's search for passion collides with the other's.

Though young Jane Austen's financially strapped parents expect her to marry the nephew of wealthy Lady Gresham, Jane herself knows that such a union will destroy her creativity and sense of self-worth. Instead, she becomes involved with Tom Lefroy, a charming but penniless apprentice lawyer who gives her the knowledge of the heart she needs for her future career as a novelist.