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Leonard Shelby is tracking down the man who raped and murdered his wife. The difficulty of locating his wife's killer, however, is compounded by the fact that he suffers from a rare, untreatable form of short-term memory loss. Although he can recall details of life before his accident, Leonard cannot remember what happened fifteen minutes ago, where he's going, or why.

"Nihil" tells the story of Adam, a young man who seems to be ready and determined to start his professional life in the city. New to the city, to its busy and quick rhythm, Adam tries to keep pace and enthusiasm but, among thousands and thousands of other strangers, he is subconsciously afraid to disappear: “When nobody’s watching, do I exist?”. Adam suddenly wakes up in the middle of a lavender field, cold and lost. Asking for help, Adam seems to be ignored by all the odd people he encounters until he realises that he is not being ignored but unseen.

In the year 2035, convict James Cole reluctantly volunteers to be sent back in time to discover the origin of a deadly virus that wiped out nearly all of the earth's population and forced the survivors into underground communities. But when Cole is mistakenly sent to 1990 instead of 1996, he's arrested and locked up in a mental hospital. There he meets psychiatrist Dr. Kathryn Railly and the son of a famous virus expert who may hold the key to the Army of the 12 Monkeys; thought to be responsible for unleashing the killer disease.