Éléonore
Marcy the Intern
Mr. Bélanger
Jonathan
Denis
Richard (Businessman #3)

For a long time, Natalie, an Australian architect living in New York City, had always believed that what she had seen in rom-coms is all fantasy. But after thwarting a mugger at a subway station only to be knocked out while fleeing, Natalie wakes up and discovers that her life has suddenly become her worst nightmare—a romantic comedy—and she is the leading lady.

On New Year's night, Sandro suffers a heart attack and needs to have an emergency transplant. He ends up receiving the heart of Isadora, a transvestite owner of a beauty salon who had died a few moments before, victim of a runover. After the transplant, Isadora, in spirit, starts to follow the publicist's steps. Meanwhile, Sandro begins to notice changes in his behavior and begins to see the world in a different way.

Charlie Kaufman is a confused L.A. screenwriter overwhelmed by feelings of inadequacy, sexual frustration, self-loathing, and by the screenwriting ambitions of his freeloading twin brother Donald. While struggling to adapt "The Orchid Thief," by Susan Orlean, Kaufman's life spins from pathetic to bizarre. The lives of Kaufman and Orlean's book become strangely intertwined as each one's search for passion collides with the other's.