Markopoulos called Lysis “a study in stream-of-consciousness poetry of a lost, wandering, homosexual soul” and felt that the film foreshadowed The Illiac Passion.
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Eva and David have a complicated mother-son relationship. They try to reach each other but do not quite know how. One problem is the language barrier, as David is deaf and Eva is not very good at sign language. After moving back to her country of birth, Eva comes to Sweden on a short visit, where she discovers what so many parents do throughout the lives of their offspring - your children never cease to surprise you.

"In medical terminology, absence of genitalia in females is referred to as "gynatresia". In other words, an extreme defect that goes beyond a mere illness" Adachi's follow-up to Bowl using the figure of a woman suffering from an unusual sexual aliment has often been taken as a controversial allegory for the political stalemate of the Leftist student movement after their impressive wave of massive fiery protests failed to defeat the neo-imperialist Japan-US Security Treaty. The ritualistic solemnity of the charged sexual scenes contribute to the oneiric qualities of Closed Vagina which Adachi would later insist was an open work, not meant to deliver any kind of deliberate political message. - Harvard Film Archive

A non-binary teen is kicked out of their North Carolina home after coming out to their ultra-religious parents. As a result, they move in with their estranged sister and her husband. Though the two are welcoming, they continue to struggle with anxiety further exacerbated by their parents' rejection. As such, they try to keep a low profile at school. However, after they meet a proudly bisexual classmate, their life begins to look a little more hopeful.