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Americans consume 75% of the world’s prescription drugs. After losing his own brother to the growing epidemic of prescription drug abuse, documentarian Chris Bell sets out to demystify this insidious addiction. Bell’s examination into the motives of big pharma and doctors in this ever-growing market leads him to meet with experts on the nature of addiction, survivors with first-hand accounts of their struggle, and whistleblowers who testify to the dollar-driven aims of pharmaceutical corporations. Ultimately his investigation will point back to where it all began: his own front door.

This documentary follows the lives of five Japanese individuals to explore how depression is perceived in Japan and how the marketing of anti-depressants since the late 1990s has shifted public awareness. Once a term used only by psychiatric professionals, "utsu" is now commonly used as anti-depressant use has surged.

Every day in the United States, law enforcement agencies at the local, state, and federal levels—including the FBI and DEA—use investigative resources to target the supply side in the war against drugs. But, even with numerous law enforcement successes in this area, the demand for drugs continues. And, one of the more worrisome trends is a growing epidemic of prescription opiate and heroin abuse, especially among young people.

Oceana, West Virginia—known as “Oxyana” after its residents’ epidemic abuse of OxyContin—is a tragically real example of the insidious spread of drug dependency throughout the country. Set against an abandoned coal mining landscape to the melodies of Deer Tick’s haunting score, this unflinchingly intimate documentary probes the lives of Oceana’s afflicted and exposes the day-to-day experience of a town living in the harsh grip of addiction.

Desperate to be free from her drunken, unloving mother Diane, the beautiful, scheming young Mini seduces her stepfather Martin and soon convinces him to join her in a sadistic scheme to have Diane declared insane. But their conspiracy soon escalates to murder and when John Garson, a young detective starts investigating, Martin and Mini begin to turn on each other.

Artistic lovers, Viv and Jay, have become trapped in a vicious cycle of codependent heroin addiction. But when Viv’s wealthy parents hire an interventionist to take Viv to rehab, the couple decides to set off on their own with the help of a suboxone prescription... all they have to do is survive a harrowing night through drug withdrawal.