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Teenager Riley's mind headquarters is undergoing a sudden demolition to make room for something entirely unexpected: new Emotions! Joy, Sadness, Anger, Fear and Disgust, who’ve long been running a successful operation by all accounts, aren’t sure how to feel when Anxiety shows up. And it looks like she’s not alone.

In 1970s Iran, Marjane 'Marji' Satrapi watches events through her young eyes and her idealistic family of a long dream being fulfilled of the hated Shah's defeat in the Iranian Revolution of 1979. However as Marji grows up, she witnesses first hand how the new Iran, now ruled by Islamic fundamentalists, has become a repressive tyranny on its own.

In a sterile white examination room, a young woman is asked by a doctor to undress completely. An exhaustive examination of the protagonist’s skin begins during which every centimetre, the palm of her hand, the sole of her foot, the back and also the genital area are closely scrutinised. The doctor meticulously probes every nook and cranny of the young woman’s outer shell until she is able to identify a suspicious birthmark. A timely appointment to remove the mole is made.

Kiko, a Japanese illustrator on assignment in France, gets suddenly overwhelmed by a strange new inspiration, while she realizes she's been spying on a gay couple on the beach next to the chapel where she's working. Obsessed by such a vision, she will continue spying on those men and drawing them secretly. These drawings will slowly push her towards an encounter that will change her life and break the barriers she created around her.