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Max Lowe is a Houston surgeon who has grown weary of the bureaucracy of American medicine. When he loses a patient on the operating table, Max impulsively decides to leave America and travel to India in the hope of finding himself. Not long after he arrives in Calcutta, Max is attacked by a group of thugs and left without money or a passport.

In 1870s India, Charulata is an isolated, artistically inclined woman who sees little of her busy journalist husband, Bhupati. Realizing that his wife is alienated and unhappy, he convinces his cousin, Amal, to spend time with Charulata and nourish her creative impulses. Amal is a fledgling poet himself, and he and Charulata bond over their shared love of art.

Apu and his family have moved away from the country to live in the bustling holy city of Benares. As he progresses from wide-eyed child to intellectually curious teenager, eventually studying in Kolkata, we witness his academic and moral education, as well as the growing complexity of his relationship with his mother.

A well-off family is paid an unexpected, and rather unwanted, visit by a man claiming to be the woman's long lost uncle. The initial suspicion with which they greet the man slowly dissolves as he regales them with stories of his travels, tales that are at odds with their conventional middle class perspective on the world.