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Famed monster slayer Gabriel Van Helsing is dispatched to Transylvania to assist the last of the Valerious bloodline in defeating Count Dracula. Anna Valerious reveals that Dracula has formed an unholy alliance with Dr. Frankenstein's monster and is hell-bent on exacting a centuries-old curse on her family.

Bud and Lou, two stranded American archaeologists, run afoul of an Egyptian cult with big plans to resurrect the mummified corpse of Klaris, guardian of his Princess Ara's treasure-filled tomb. When Lou accidentally eats the cursed medallion needed to find the ancient treasure, the two become targets of the cult's leader, his goons, a mysterious femme fatale, and the mummy of Klaris himself!

A scientist working on cures for rare afflictions, such as a bone softening agent made from molds to allow him to correct the spinal deformity of his nurse, finds the physical causes of lycanthropy in wolf-man Larry Talbot and of vampirism in Count Dracula, but himself becomes afflicted with homicidal madness while exchanging blood with Dracula.