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Boston is being terrorized by a series of seemingly random murders of women. Based on the true story, the film follows the investigators path through several leads before introducing the Strangler as a character. It is seen almost exclusively from the point of view of the investigators who have very few clues to build a case upon.

Officer Blanca Bravo arrives in Juarez, Mexico — a grim nexus of corporate colonialism and sexual tourism — to investigate a rash of killings targeting female migrant workers. But with no help from the locals, bringing the responsible parties to justice becomes a frustrating exercise. As Bravo rails against indifference and local corruption, she finds herself on a collision course with Mickey Santos, a Mexican mogul with a taste for young prostitutes.

Clay is a young man in a small town who witnesses his friend, Earl, kill himself because of the ongoing affair that Clay was having with the man's wife, Amanda. Feeling guilty, Clay now resists the widow when she presses him to continue with the affair. Clay unknowingly befriends a serial killer named Lester Long who murders the widow in an attempt to "help" his "fishing buddy."

Wes Clayton is a lawman and a bishop in a Mormon community called Brigham. The town is shaken when a woman from California is found murdered. Clayton and his young deputy work with an FBI agent sent to investigate. As a civil and spiritual leader in the frightened town, Clayton must uncover the town's deepest secrets, find the murderer and keep Brigham from ripping itself apart.