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When an employee at an illegal gambling den dies suspiciously, her sister, Nancy, looks into the situation and falls for Johnny O'Clock, a suave partner in the underground casino. Selfish and non-committal by nature, Johnny slowly begins to return Nancy's affection and decides to run away with her, but conflict within his business threatens their plans. As Johnny tries to distance himself from the casino, his shady past comes back to haunt him.

Actor Lester Blaine has all but landed the lead in Myra Hudson's new play when Myra vetoes him because, to her, he doesn't look like a romantic leading man. On a train from New York to San Francisco, Blaine sets out to prove Myra wrong...by romancing her. Is he sincere, or does he have a dark ulterior motive?

George Stroud, a crime magazine's crusading editor, has to postpone a vacation with his wife - again - when a glamorous blonde is murdered and he is assigned by his publishing boss to find the killer. As the investigation proceeds to its conclusion, Stroud must try to disrupt his ordinarily brilliant investigative team as they increasingly build evidence that he is the killer.

Rose Loomis and her older, gloomier husband, George, are vacationing at a cabin in Niagara Falls. The couple befriend Polly and Ray Cutler, who are honeymooning in the area. Polly begins to suspect that something is amiss between Rose and George, and her suspicions grow when she sees Rose in the arms of another man. While Ray initially thinks Polly is overreacting, things between George and Rose soon take a shockingly dark turn.

Nick Garcos comes back from his tour of duty in World War II planning to settle down with his girlfriend, Polly Faber. He learns, however, that his father was recently beaten and burglarized by mob-connected trucker Mike Figlia, and Nick resolves to get even. He partners with prostitute Rica, and together they go after Mike, all the while getting pulled further into the local crime underworld.