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A social misfit, Willard is made fun of by his co-workers, and squeezed out of the company started by his deceased father by his boss. His only friends are a couple of rats he raised at home, Ben and Socrates. However, when one of them is killed at work, he goes on a rampage using his rats to attack those who have been tormenting him.

In a backwoods cabin, a boy called Little Man lives with his dad (a trapper), his older sister Missy, and his younger sister Kid, who is feral, spends most of her time under the table, and can imitate the sound of any animal. Their mother is dead. One day, while dad's in town selling skins, Missy teases Kid and gets bitten. There's Hell to pay when dad gets home, and Kid runs off into the night to spend it with her animal friends. Little Man, who narrates much of the story as well as his reflections in a whisper, must sort out loss and emptiness.

Alex, an up-and-coming TV journalist, returns to her hometown of Danford as local police attempt to cope with a series of brutal murders. The small town plunges into a state of panic and the murders--clearly the work of a monster, more beast than man--continue... until Alex comes face to face with the evil itself.